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KMID : 0363320040250010092
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Journal of Korean Oriental Internal Medicine
2004 Volume.25 No. 1 p.92 ~ p.105
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The Anti-tumor Effect of BoJungIkKeeHapDaeChilKi-Tang with Doxorubicin in MKN-45
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Lee Yun-Hee
Kim Bong-Suk
Oh Jung-Han
Lim Hee-Yong
Kim Dong-Woo
Choi Bin-Hye
Byun Joon-Seok
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Abstract
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In order to evaluate the anti-tumor and synergic effect of BoJungIkKeeHapDaeChilKi-Tang on doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and BoJungIkKeeHapDaeChilKi-Tang with their concomitant treatment against MKN-45(Human stomach carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst MKN-45 cell lines. BoJungIkKeeHapDaeChilKi-Tang has only mimic direct anti-tumor effect against to MKN-45 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that BoJungIkKeeHapDaeChilKi-Tang extracts were reduced by the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and BoJungIkKeeHapDaeChilKi-Tang extracts.
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KEYWORD
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BoJungIkKeeHapDaeChilKi-Tang, doxorubicin, anti-tumor effect, MKN-45
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